BAY 2402234
CAS No. 2225819-06-5
BAY 2402234 ( BAY2402234;BAY-2402234 )
Catalog No. M13555 CAS No. 2225819-06-5
BAY 2402234 (BAY2402234) is a novel potent, selective, orally bioavailable DHODH inhibitor with IC50 of 1.2 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 233 | Get Quote |
|
5MG | 348 | Get Quote |
|
10MG | 537 | Get Quote |
|
25MG | 858 | Get Quote |
|
50MG | 1161 | Get Quote |
|
100MG | 1557 | Get Quote |
|
200MG | Get Quote | Get Quote |
|
500MG | Get Quote | Get Quote |
|
1G | Get Quote | Get Quote |
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Biological Information
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Product NameBAY 2402234
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NoteResearch use only, not for human use.
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Brief DescriptionBAY 2402234 (BAY2402234) is a novel potent, selective, orally bioavailable DHODH inhibitor with IC50 of 1.2 nM.
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DescriptionBAY 2402234 (BAY2402234) is a novel potent, selective, orally bioavailable DHODH inhibitor with IC50 of 1.2 nM (human full-length DHODH); binds the ubiquinone binding site of DHODH between the N-terminal helices; causes dose-dependent upregulation of CD11b with EC50s of 3.16 nM in MOLM-13 cells and 0.96 nM in HEL cells, inhibits the proliferation of THP-1 cells with an IC50 of 2.6 nM, as well as nine other leukemia cell lines representing diverse AML subtypes (IC50=0.08-8.2 nM); BAY 2402234 shows monotherapy efficacy and differentiation induction across multiple AML subtypes both in vitro and in vivo.Blood Cancer Phase 1 Clinical
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SynonymsBAY2402234;BAY-2402234
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PathwayOthers
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TargetOther Targets
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RecptorOther Targets
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Research AreaCancer
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IndicationBlood cancer
Chemical Information
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CAS Number2225819-06-5
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Formula Weight520.84
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Molecular FormulaC21H18ClF5N4O4
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Purity>98% (HPLC)
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SolubilityDMSO : 125 mg/mL 240.00 mM
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SMILESFC1=C(NC(C2=CC(F)=C(N3N=C(CO)N(CC)C3=O)C=C2O[C@@H](C)C(F)(F)F)=O)C(Cl)=CC=C1
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Chemical Name(S)-N-(2-chloro-6-fluorophenyl)-4-(4-ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)-5-fluoro-2-((1,1,1-trifluoropropan-2-yl)oxy)benzamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Christian S, et al. Leukemia. 2019 Apr 2. doi: 10.1038/s41375-019-0461-5.
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