BAY 2402234

CAS No. 2225819-06-5

BAY 2402234 ( BAY2402234;BAY-2402234 )

Catalog No. M13555 CAS No. 2225819-06-5

BAY 2402234 (BAY2402234) is a novel potent, selective, orally bioavailable DHODH inhibitor with IC50 of 1.2 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 233 Get Quote
5MG 348 Get Quote
10MG 537 Get Quote
25MG 858 Get Quote
50MG 1161 Get Quote
100MG 1557 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    BAY 2402234
  • Note
    Research use only, not for human use.
  • Brief Description
    BAY 2402234 (BAY2402234) is a novel potent, selective, orally bioavailable DHODH inhibitor with IC50 of 1.2 nM.
  • Description
    BAY 2402234 (BAY2402234) is a novel potent, selective, orally bioavailable DHODH inhibitor with IC50 of 1.2 nM (human full-length DHODH); binds the ubiquinone binding site of DHODH between the N-terminal helices; causes dose-dependent upregulation of CD11b with EC50s of 3.16 nM in MOLM-13 cells and 0.96 nM in HEL cells, inhibits the proliferation of THP-1 cells with an IC50 of 2.6 nM, as well as nine other leukemia cell lines representing diverse AML subtypes (IC50=0.08-8.2 nM); BAY 2402234 shows monotherapy efficacy and differentiation induction across multiple AML subtypes both in vitro and in vivo.Blood Cancer Phase 1 Clinical
  • Synonyms
    BAY2402234;BAY-2402234
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Other Targets
  • Research Area
    Cancer
  • Indication
    Blood cancer

Chemical Information

  • CAS Number
    2225819-06-5
  • Formula Weight
    520.84
  • Molecular Formula
    C21H18ClF5N4O4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 125 mg/mL 240.00 mM
  • SMILES
    FC1=C(NC(C2=CC(F)=C(N3N=C(CO)N(CC)C3=O)C=C2O[C@@H](C)C(F)(F)F)=O)C(Cl)=CC=C1
  • Chemical Name
    (S)-N-(2-chloro-6-fluorophenyl)-4-(4-ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)-5-fluoro-2-((1,1,1-trifluoropropan-2-yl)oxy)benzamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Christian S, et al. Leukemia. 2019 Apr 2. doi: 10.1038/s41375-019-0461-5.
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