BAY 2402234 ( BAY2402234;BAY-2402234 )

Catalog No. M13555 CAS No. 2225819-06-5

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Datasheet

HNMR

HPLC

MSDS

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Product Name

BAY 2402234
Note

Research use only, not for human use.
Brief Description

BAY 2402234 (BAY2402234) is a novel potent, selective, orally bioavailable DHODH inhibitor with IC50 of 1.2 nM.
Description

BAY 2402234 (BAY2402234) is a novel potent, selective, orally bioavailable DHODH inhibitor with IC50 of 1.2 nM (human full-length DHODH); binds the ubiquinone binding site of DHODH between the N-terminal helices; causes dose-dependent upregulation of CD11b with EC50s of 3.16 nM in MOLM-13 cells and 0.96 nM in HEL cells, inhibits the proliferation of THP-1 cells with an IC50 of 2.6 nM, as well as nine other leukemia cell lines representing diverse AML subtypes (IC50=0.08-8.2 nM); BAY 2402234 shows monotherapy efficacy and differentiation induction across multiple AML subtypes both in vitro and in vivo.Blood Cancer Phase 1 Clinical
Synonyms

BAY2402234;BAY-2402234
Pathway

Others
Target

Other Targets
Recptor

Other Targets
Research Area

Cancer
Indication

Blood cancer

CAS Number

2225819-06-5
Formula Weight

520.84
Molecular Formula

C21H18ClF5N4O4
Purity

>98% (HPLC)
Solubility

DMSO : 125 mg/mL 240.00 mM
SMILES

FC1=C(NC(C2=CC(F)=C(N3N=C(CO)N(CC)C3=O)C=C2O[C@@H](C)C(F)(F)F)=O)C(Cl)=CC=C1
Chemical Name

(S)-N-(2-chloro-6-fluorophenyl)-4-(4-ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)-5-fluoro-2-((1,1,1-trifluoropropan-2-yl)oxy)benzamide

1. Christian S, et al. Leukemia. 2019 Apr 2. doi: 10.1038/s41375-019-0461-5.

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